Figure1 (IMAGE)

Sungkyunkwan University External Affairs Division (PR team)

Figure1

Caption

The gut microbial metabolite DHB promotes the formation of antigen-specific, stem-like CD8+ T cells by suppressing glycolysis and modulating the Akt-mTORC1-Myc pathway. Oral nano-emulsion formulation of DHB significantly improves its bioavailability, demonstrating potent anti-tumor efficacy when combined with immune checkpoint inhibitors.

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Han, K., Cho, Y.S., Takahashi, M. et al. Oral nano-delivery of a gut microbial metabolite enhances T cell stemness for cancer immunotherapy. Nat. Nanotechnol. (2026). https://doi.org/10.1038/s41565-026-02235-9

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