Schematic illustration of binary macrophage states associated with interferon-responsive immune activation and PGE₂-related immunosuppressive features and their relationship with differential responses to immunotherapy in gastric cancer. (IMAGE)

Science China Press

Schematic illustration of binary macrophage states associated with interferon-responsive immune activation and PGE₂-related immunosuppressive features and their relationship with differential responses to immunotherapy in gastric cancer.

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Binary macrophage states composed of Mac-CXCL10 and Mac-OLR1 in the tumor microenvironment are associated with differential regulation of CD8⁺ T-cell interferon signaling and reflect a balance between immune activation and PGE₂-related immunosuppressive features in gastric cancer. Created with BioRender.com.

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