Microglia-targeted evodiamine-loaded liposomes alleviate sepsis-induced brain inflammation. (IMAGE)

Science China Press

Microglia-targeted evodiamine-loaded liposomes alleviate sepsis-induced brain inflammation.

Caption

ANXA2-targeted L-A-P@E was constructed and administered intravenously to cross the blood-brain barrier and reach the brain. In microglia, L-A-P@E released evodiamine, inhibited ANXA2-associated inflammatory signaling, reduced neuroinflammation and neuronal apoptosis, and thereby exerted neuroprotective effects.

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