MAPK-driven Nckap5+ macrophage expansion in Pneumocystis pneumonia (IMAGE)

Chinese Medical Journals Publishing House Co., Ltd.

MAPK-driven Nckap5+ macrophage expansion in Pneumocystis pneumonia

Caption

scRNA-seq of PCP lungs in SCID mice revealed expansion of Ccr2⁺ monocyte-derived Nckap5⁺ macrophages with anti-inflammatory and pro-proliferative traits. MAPK pathway inhibition via Adezmapimod reversed Nckap5 induction and suppressed Il10, Arg1, and Tgfβ expression, identifying Nckap5⁺ macrophages as a potential therapeutic target in PCP.

Credit

Lin Gu / Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University

Usage Restrictions

This image is for use with this news release only.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.