SIRT3 serves as the “head goose molecule” for fighting metabolic diseases. (IMAGE)
Caption
ECSH1: enoyl-coenzyme A (CoA) hydratase short chain 1; ACC: acetyl-CoA carboxylase; LKB1: liver kinase B1; LCAD: long-chain acyl-CoA dehydrogenase; VLCAD: very-long-chain acyl-CoA dehydrogenase; Hsp: heat shock protein; GLUT: glucose transporter; GDH: glutamate dehydrogenase; OTC: ornithine transcarbamylase; PDHE1α: pyruvate dehydrogenase E1 subunit alpha 1; cypD: cyclophilin D; AceCS2: acetyl-CoA synthetase 2; PTEN: phosphatase and tensin homolog; IDH2: isocitrate dehydrogenase 2; GOT2: glutamate oxaloacetate transaminase 2; p53: tumor protein 53; HMGCS2: 3-hydroxy-3-methylglutaryl-CoA synthase 2; FoxO3a: forkhead box protein O3; PINK1: phosphatase and tensin homolog-induced putative kinase 1; SDHA: succinate dehydrogenase complex flavoprotein subunit A; ATP5O: ATP synthase subunit O; MRPL10: mitochondrial ribosomal protein L10; NDUFA: nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase subunit A1; PRDX3: peroxiredoxin 3; SOD2: superoxide dismutase 2; OPA1: optic atrophy 1; IL: interleukin; NF-κB: nuclear factor kappa B; NLRP3: nucleotide-binding oligomerization domain (NOD)-like receptor thermal protein domain-associated protein 3; PPAR-α: peroxisome proliferator-activated receptor alpha; AD: Alzheimer’s disease; DCM: dilated cardiomyopathy; MIRI: myocardial ischemia‒reperfusion injury; DLBCL: diffuse large B-cell lymphoma; PAH: pulmonary arterial hypertension.
Credit
Hu Li, Tong Wang, Biao Dong, Zonggen Peng, Jiandong Jiang
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