Establishment of human trophoblast stem cells (hTSCs) from late gestation placentas (IMAGE)

Kumamoto University

Establishment of human trophoblast stem cells (hTSCs) from late gestation placentas

Caption

Efficient generation of hTSCs from late gestation placentas has been challenging. In this study, we introduced factors that suppress cellular senescence together with the stemness-associated gene SALL4 into late gestation placental trophoblast cells. In addition, we transiently inhibited a group of genes that restrict cell proliferation. This combined approach enabled the efficient establishment of hTSCs from late gestation placentas.

Credit

Hiroaki Okae (Kumamoto University)

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CC BY-NC

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