Figure 1. Discovery of Early Responsive Excitatory Neurons (ERENs) through single-nucleus RNA sequencing (snRNA-seq) (IMAGE)

Institute for Basic Science

Figure 1. Discovery of Early Responsive Excitatory Neurons (ERENs) through single-nucleus RNA sequencing (snRNA-seq)

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Comparison of snRNA-seq data from wild-type and Alzheimer's disease model mice revealed a distinct population of excitatory neurons that was selectively enriched in the Alzheimer's disease model. This population was designated Early-Responsive Excitatory Neurons (ERENs) (top). Weighted gene co-expression network analysis (WGCNA) identified gene modules associated with ERENs, with ERBB4 emerging as a prominent candidate molecule within the turquoise module. (bottom).

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