Discovery of a Novel Rat Model That Spontaneously Develops Chronic Kidney Disease (IMAGE)
Caption
Txn1-F54L mutation in rat modelreduces thioredoxin activity and triggers oxidative stress, mitochondrial damage, inflammation, and multiple forms of regulated cell death in kidney tissue. These processes collectively promote CKD. The study provides translational insights and a foundation for developing treatment options for CKD, targeting oxidative stress-induced pathways.
Credit
Professor Iori K. Ohmori from Okayama University, Japan
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