Figure1 (IMAGE)

Sungkyunkwan University External Affairs Division (PR team)

Figure1

Caption

An engineered Trojan Mycobacterium, developed via a “peeling-off and masking-up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen-targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors. Preoperative administration effectively thwarts postsurgical tumor recurrence and sensitizes refractory landscapes to checkpoint blockades.

Credit

J.-H. Choi, S. N. Lee, J. H. Heo, S. Park, S. H. Park, and Y. T. Lim, “ Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion.” Advanced Materials (2026): e74513. https://doi.org/10.1002/adma.74513

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