Schematic representation of competitive binding between GATA1/NFY and ZBTB7A/BCL11A complexes at the γ-globin promoter. (IMAGE)

Shanghai Jiao Tong University Journal Center

Schematic representation of competitive binding between GATA1/NFY and ZBTB7A/BCL11A complexes at the γ-globin promoter.

Caption

Schematic representation of competitive binding between GATA1/NFY and ZBTB7A/BCL11A complexes at the γ-globin promoter. During fetal erythroid maturation, GATA1 and NFY form an activating protein complex that binds the γ-globin promoter. In contrast, ZBTB7A and BCL11A form a repressor complex that mediates the γ-to-β-globin switching process.

Credit

Xin-Ran Wei; Xiao-Hui Huang; Shu-Er Liu; Yu-Jie Zhao; Mei Chen; Di Jin; Yue Gao; Yi-Hui Zhang; Hui-Xin Ai; Yan-Lin Ma; Zheng Liu.

Usage Restrictions

Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted.

License

CC BY-NC-ND

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.