Dissociation of the four-part TTR protein (IMAGE)

Scripps Research Institute

Dissociation of the four-part TTR protein

Caption

Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers.

Credit

Jan-Hannes Schäfer, Scripps Research

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