Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging (IMAGE)
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Figure 7. Changes in circulating and tissue levels of CXCL13 and IL-10 in wildtype and Ptpn6Ala457Thr mice during aging. (A) Plasma and hepatic (B) CXCL13 levels measured using the Bio-Plex Pro Mouse Chemokine Assay Kit V. (C) Plasma IL-10 levels measured using the Bio-Plex Pro Mouse Chemokine Assay Kit V. (D) Splenic IL-10 levels measured using the DuoSet Mouse IL-10 Kit. (E) Mesenteric white adipose tissue IL-10 levels measured using the DuoSet Mouse IL-10 Kit. (F) Hepatic IL-10 levels measured using the Bio-Plex Pro Mouse Chemokine Assay Kit V. Data are represented as mean ± SEM. Statistical significance was determined using unpaired two-tailed Student’s t test with *p < 0.05, **p < 0.01, ***p < 0.001. Sample sizes: Old WT, n=10-11 and Ptpn6Ala457Thr, n=16-18.
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