LARGE reveals age-related dynamics of the gut antibiotic resistome (IMAGE)

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LARGE reveals age-related dynamics of the gut antibiotic resistome

Caption

Overview of LARGE (language model-based Antibiotic Resistance Gene Explorer). Trained on 64,317 ARG and non-ARG sequences with two frozen language-model encoders (ESM-2 and FGeneBERT), LARGE predicts resistance type, resistance mechanism, and gene name. Applied to gut metagenomes from three Chinese cohorts, it identifies species-level changes in the antibiotic resistome during human aging and links them to age-related chronic diseases.

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hLife

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