Figure 1. (IMAGE)

Higher Education Press

Figure 1.

Caption

Model of glucose sensing in intestinal L cells for GLP-1 secretion. In the postprandial state, high glucose is transported into L cells via GLUT2 and binds glucokinase (GK). The glucose-bound GK then interacts with and inhibits KATP channels, causing plasma membrane depolarization and robust GLP-1 secretion (upper). Under low glucose conditions, SGLT1 co-transports Na⁺ and glucose into L cells, leading to membrane depolarization that mediates basal GLP-1 secretion (lower).

Credit

HIGHER EDUCATION PRESS

Usage Restrictions

none

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.