Psycho-cardiovascular interaction network (PCIN): from mind to heart via multilevel mechanisms. (IMAGE)

West China Hospital of Sichuan University

Psycho-cardiovascular interaction network (PCIN): from mind to heart via multilevel mechanisms.

Caption

Psycho-cardiovascular interaction network (PCIN): from mind to heart via multilevel mechanisms. The psycho-cardiovascular interaction network (PCIN) links psychological and psychiatric conditions with cardiovascular health and disease through bidirectional associations. System-level mechanisms include hypothalamic–pituitary–adrenal (HPA) axis and autonomic nervous system (ANS) imbalance, chronic inflammation, platelet activation, unhealthy behaviors, and sleep/circadian disruption. These converge on key signaling pathways: brain-derived neurotrophic factor (BDNF), prokineticin/prokineticin receptor (PROK/PKR), mitogen-activated protein kinase (MAPK), 5-hydroxytryptamine/5-HT2A receptor (5-HT/5-HT2A-R), and NOD-like receptor protein 3 (NLRP3).

Credit

Precision Clinical Medicine

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CC BY

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