Hitting two organs with one common signaling regulator (IMAGE)
Caption
How the pancreas and liver work together to maintain blood glucose, and how CA8 changes in
opposite directions in a mouse model of type 2 diabetes. After eating, pancreatic beta cells
release insulin, while during fasting, the liver produces glucose. In ob/ob mice, CA8 increased in
pancreatic islets but decreased in hepatocytes, changes that may contribute to reduced insulin
secretion and excessive hepatic glucose production. Restoring CA8 in the liver suppressed
excessive glucose production. The findings suggest that future therapies may need to account
for the distinct roles of the same pathway in different organs.
Credit
Otani, Fauzi, and Murakami / KyotoU
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