KAIST Uses Wireless Neural Chip to Track Brain Changes in Real Time After Alzheimer’s Drug Administration (IMAGE)
Caption
Figure 1. Structure and operating principle of the implantable wireless neural chip that measures acetylcholine changes in the brain
The sensing layer, made of porous chitosan and silver-platinum (Ag@Pt) nanowires, converts hydrogen peroxide produced by the enzyme reaction of acetylcholine into electrical signals, and a miniaturized measurement circuit transmits the measured signals via Bluetooth. The double-sided electrodes are designed to reduce interference from other molecules by using the difference between signals from electrodes with and without the enzymes. The micro-LED is used to stimulate nerve cells with light. Signal changes in response to light stimulation were confirmed in mice, and drug responses were measured wirelessly in minipigs.
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KAIST
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