U-NK cells promote hematopoietic engraftment and survival after allogeneic stem cell transplantation (IMAGE)
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In a cohort of 976 patients who underwent allogeneic hematopoietic stem cell transplantation after myeloablative conditioning, the presence of donor-derived unlicensed natural killer cells (U-NK cells) was associated with faster hematopoietic recovery and improved clinical outcomes. Mechanistic studies showed that U-NK cells enhanced the in vitro colony-forming capacity of hematopoietic stem and progenitor cells. In vivo, U-NK cell infusion accelerated donor neutrophil and platelet engraftment and increased the numbers of granulocyte-monocyte progenitors (GMP), megakaryocyte-erythroid progenitors (MEP), and multipotent progenitors (MPP) during the early post-transplantation period. These effects were accompanied by increased plasma levels of factor VII and serum amyloid A1 (SAA1), providing further insight into the mechanisms by which U-NK cells may promote hematopoietic recovery.
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