Elevated creatinine levels do not necessarily indicate impaired kidney function: pre-treatment cystatin C measurement is key to assessment (IMAGE)
Caption
Figure: Elevated creatinine levels do not necessarily indicate impaired kidney function: pre-treatment cystatin C measurement is key to assessment
In 63 patients with breast cancer receiving abemaciclib, serum creatinine and cystatin C were measured before and during treatment, and polymorphisms of renal transporters involved in creatinine secretion were analyzed. Serum creatinine rose in 62 of the 63 patients, whereas cystatin C fell in 28 of the 29 patients who had a pre-treatment measurement. Patients with the SLC47A1 rs2289669 GG genotype, in which MATE1 function is preserved, tended to show a larger creatinine rise. Measuring cystatin C before treatment helps avoid unnecessary dose reductions, treatment interruptions, and additional tests.
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Data panels adapted from Watanabe H, et al. Clin Pharmacol Ther (2026). All icons were obtained from bioicons.com and modified.
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