Copper-Catalyzed Enantioselective B–H Insertion for the Synthesis of Chiral α-Perfluoroalkyl Boranes with Vicinal Boron/Carbon Stereocenters (IMAGE)

Science Exploration Press

Copper-Catalyzed Enantioselective B–H Insertion for the Synthesis of Chiral α-Perfluoroalkyl Boranes with Vicinal Boron/Carbon Stereocenters

Caption

A Cu/L*-catalyzed asymmetric B–H insertion of 2-arylpyridine-boranes with α-aryl-α-perfluoroalkyl diazomethanes enables the efficient construction of chiral α-perfluoroalkyl boranes bearing vicinal boron and carbon stereocenters. The transformation proceeds under mild conditions, affording products in up to 85% yield, 99% ee, and dr > 20:1.

Credit

© Bo-Han Zhu, Qiuling Song, et al., 2026. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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