Genetically determined heterogeneous treatment effects of Helicobacter pylori eradication for targeted gastric cancer prevention (IMAGE)

Innovation Press

Genetically determined heterogeneous treatment effects of Helicobacter pylori eradication for targeted gastric cancer prevention

Caption

  • Population-based Helicobacter pylori screen-and-treat is a priority for gastric cancer prevention.
  •  Host genetic factors modify the preventive efficacy of H. pylori eradication against gastric cancer.
  • A polygenic treatment benefit score (PTBS) identifies individuals with preventive benefit from eradication.
  • PTBS can be incorporated to refine the screen-and-treat strategies and post-treatment risk management.

Credit

Liu Z., Wang Y., Xu H., et al., (2026). Genetically determined heterogeneous treatment effects of Helicobacter pylori eradication for targeted gastric cancer prevention. The Innovation 7(10), 101402.

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Credit must be given to the creator.

License

CC BY

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