From orbit to the clinic: a space-based framework for rare pediatric disease modeling. (IMAGE)

West China Hospital of Sichuan University

From orbit to the clinic: a space-based framework for rare pediatric disease modeling.

Caption

From orbit to the clinic: a space-based framework for rare pediatric disease modeling. A proposed translational cycle in which patient-derived hiPSCs and 3D organoids from children with mitochondrial disorders or congenital heart disorders (CHDs) are exposed to spaceflight stressors. Space acts as a discovery platform to uncover or amplify disease-relevant mechanisms, which are then validated in terrestrial models, including organoids, organ-on-chip systems, and engineered heart tissues, to guide therapeutic development.

Credit

Precision Clinical Medicine

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License

CC BY

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