From animal models to new approach methodologies: Opportunities and challenges (IMAGE)

Innovation Press

From animal models to new approach methodologies: Opportunities and challenges

Caption

The graphical abstract contrasts traditional animal experimentation in the drug R&D pipeline—spanning disease modeling, efficacy assessment, and drug toxicity—with the transition to new approach methodologies (NAMs), including organoids, microphysiological systems, and computational modeling, bridged by the FDA's new paradigm. A comparison table outlines six dimensions where the two approaches differ, from physiological relevance and system simulation to screening throughput and regulatory validation.

Credit

Zhu H., Lin X., Weng Q., et al., (2026). From animal models to new approach methodologies: Opportunities and challenges. The Innovation 7(11), 101260.

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License

CC BY

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