Macrophage Polarization Imbalance and LPC Metabolic Reprogramming in Immune Thrombocytopenia (IMAGE)

Chinese Medical Journals Publishing House Co., Ltd.

Macrophage Polarization Imbalance and LPC Metabolic Reprogramming in Immune Thrombocytopenia

Caption

(A) Flow cytometry scatter plots of M1/M2 macrophage polarization; (B) Volcano plot of differentially expressed metabolites; (C) ELISA measurement of LPC (16:0/0:0) concentration in bone marrow supernatants; (D) Flow cytometry analysis of macrophage phagocytosis of platelets; (E) CFSE proliferation histograms from macrophage–T cell co-culture assays; (F) Schematic of passive and active ITP mouse models and time-course curves of platelet counts.

Credit

Professor Yan Liu and Associate Professor Shuwen Wang from Qilu Hospital of Shandong University, China Link: https://www.ovid.com/jnls/cmj/fulltext/10.1097/cm9.0000000000004172~lysophosphatidylcholine-induced-macrophage-polarization

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