Two routes to the target ketone (IMAGE)

Institute of Microbiology, Chinese Academy of Sciences

Two routes to the target ketone

Caption

 (A) A carbonyl reductase reduces the unwanted (1S,5R) enantiomer to an alcohol that must be esterified before it can be separated. (B) In the new route, an amine dehydrogenase aminates the unwanted enantiomer with ammonium formate; acid extraction moves the amine into water and leaves the target ketone in the organic phase, from which mirogabalin is built.

Credit

Chinese Journal of Biotechnology

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