Dual-dynamic control and metabolic rebalancing guided by toxic target discovery for efficient dencichine production (IMAGE)

Innovation Press

Dual-dynamic control and metabolic rebalancing guided by toxic target discovery for efficient dencichine production

Caption

Elucidating the toxicity mechanism caused by overexpressing serA encoding 3-phosphoglycerate dehydrogenase.

Engineering a dual-dynamic genetic circuit to improve cell growth and dencichine (β-ODAP) production.

This systematic engineering strategy enables the highest reported biosynthesis titer of β-ODAP.

Credit

Zhang Y., Wu J., Yu J., et al. (2026). Dual-dynamic control and metabolic rebalancing guided by toxic target discovery for efficient dencichine production. The Innovation Life 4:100242. https://doi.org/10.59717/j.xinn-life.2026.100242

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