Tumor recurrence and metastasis arise from the interaction of shared evolutionary programs and context-dependent modifiers (IMAGE)

International Society for Health Data Science

Tumor recurrence and metastasis arise from the interaction of shared evolutionary programs and context-dependent modifiers

Caption

This figure shows the cross-cancer mechanistic architecture: from the primary-tumor ecosystem, through clonal diversification and genomic instability, to cell-state plasticity, microenvironmental selection and dissemination, and ultimately local recurrence and distant metastasis. Clonal selection, cell-state plasticity, and microenvironmental adaptation together drive recurrence and metastasis.

Credit

Wenjun Meng, Ruicen Li, Xiaoli Mu, Xiaolong Tang, Yuxi Luo, Yingying Lei, Jinghong Xian, Guiyi Ji, Yihao Liu, Chenyu Huo, Sihan Li, Yalun Li, Jiadi Gan, Weimin Li

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