Metabolic circuitry of NADH buffering reveals a vulnerability in redox-adaptive cancer cells (IMAGE)

Innovation Press

Metabolic circuitry of NADH buffering reveals a vulnerability in redox-adaptive cancer cells

Caption

  • Glucose-6-phosphate dehydrogenase (G6PD) promotes malic enzyme 1 (ME1) activity independent of catalysis.
  • The PC-MDH1/2-ME1 circuitry supports cytosolic and mitochondrial NADH redox homeostasis.
  • Blocking PC sensitizes cancer cells to reductive stress and enhances antitumor synergy.

Credit

Li X., Hou P., Zhai X., et al., (2026). Metabolic circuitry of NADH buffering reveals a vulnerability in redox-adaptive cancer cells. The Innovation 7(9), 101365. https://doi.org/10.1016/j.xinn.2026.101365

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CC BY-NC-ND

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