GzmK impact on organs (IMAGE)

Monash University

GzmK impact on organs

Caption

Kidney sections from aged wild-type (left) and GzmK-deficient mice (right). Normal ageing is associated with enlargement of the kidney’s filtering units (glomerular hypertrophy) and substantial deposition of inflammatory complement proteins (green). In mice lacking GzmK, both glomerular enlargement and complement deposition are markedly reduced, indicating protection against age-related kidney damage.

Credit

Nicole La Gruta, Monash Biomedicine Discovery Institute (BDI)

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