The central dogma of aging (IMAGE)

Innovation Press

The central dogma of aging — Caption

The Central Dogma of Aging extends the canonical DNA→RNA→protein information flow to metabolites.

Layer-specific imbalances in anabolism, modification and catabolism propagate across levels to drive aging.

The exposome acts hierarchically on the four layers and thereby sets the aging trajectory.

This framework offers a rationale for aging interventions at any layer, and the exposome.

Credit

Zhang J., Su W., Duan J., et al., (2026). The central dogma of aging. The Innovation Life 4(4), 100262.

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