Toxic Protein Hijacks Norepinephrine to Drive Alzheimer's Disease (1 of 2) (IMAGE)

American Association for the Advancement of Science (AAAS)

Toxic Protein Hijacks Norepinephrine to Drive Alzheimer's Disease (1 of 2)

Caption

Mice treated with idazoxan, which blocks a receptor for norepinephrine, behaved similarly to control animals despite still having amyloid-beta plaques in the brain. This material relates to a paper that appeared in the Jan. 15, 2020, issue of Science Translational Medicine, published by AAAS. The paper, by F. Zhang at University of Alabama at Birmingham in Birmingham, AL; and colleagues was titled, "Amyloid β redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade."

Credit

F. Zhang <i>et al., Science Translational Medicine</i> (2019)

Usage Restrictions

Please cite the owner of the material when publishing. This material may be freely used by reporters as part of news coverage, with proper attribution. Non-reporters must contact <i>Science</i> for permission.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.