Small Molecules Binding to Amyloid Fibrils (IMAGE)

University of California - Los Angeles

Small Molecules Binding to Amyloid Fibrils

Caption

The stacked gray arrows are an artistic representation of the amyloid proteins associated with numerous diseases, including Alzheimer's. When proteins enter amyloid, they stack up like the rungs of a ladder and interfere with normal operations of biological cells. The green and red molecules are atomic representations of one of the compounds discovered by Jiang, et al., which bind to amyloid fibers. Carbon atoms are colored green, oxygen atoms are red, and nitrogen atoms are blue.

Credit

Lin Jiang, David Eisenberg/UCLA, Howard Hughes Medical Institute

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