Stem Cells Offer Hope for Spinal Muscular Atrophy (IMAGE)

American Association for the Advancement of Science (AAAS)

Stem Cells Offer Hope for Spinal Muscular Atrophy

Caption

This shows an image of genetically corrected patient specific Spinal Muscular Atrophy (SMA) motor neurons effectively integrated in the spinal cord of a SMA mouse after transplantation. The cells are stained with the gene reporter green fluorescent protein (GFP, green) and the motor neuron marker Choline acetyltransferase (ChAT, red; merged signals: yellow). The authors have demonstrated the feasibility of generating genetically corrected SMA-induced pluripotent stem cells (iPSCs) and differentiating them into motor neurons. This image relates to a paper that appeared in the Dec. 19, 2012, issue of Science Translational Medicine, published by AAAS. The paper, by S. Corti at the University of Milan in Milan, Italy, and colleagues was titled, “Genetic Correction of Human Induced Pluripotent Stem Cells from Patients with Spinal Muscular Atrophy.”

Credit

Image courtesy of Corti <i>et al</i>., UNIMI

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