Figure 1. Working principle and results of the TFOE neurostimulation. (IMAGE)

Light Publishing Center, Changchun Institute of Optics, Fine Mechanics And Physics, CAS

Figure 1. Working principle and results of the TFOE neurostimulation.

Caption

a, Schematic of TFOE enabling single neuron stimulation. A 3-nanosecond pulsed laser is delivered nto the TFOE to generate acoustic signal via the photoacoustic effect. b, Fabrication of TFOE. Multiwall CNT/PDMS mixture as the coating material casted on a metal mesh followed by a punch-through method to coat the tapered fiber tip. Optical images show the TFOE has a tip with an overall diameter of 20 microns. c, Characterization of the pressure generated by TFOE and successful stimulation showed by calcium imaging. Left: acoustic pressure generated as a function of the distance from TFOE tip. Middle left: TFOE induced stimulation of GCaMP6f expressing single neuron. Middle right: TFOE selectively stimulation of axon (red) and dendrites (yellow and green) of a multipolar neuron. Right: TFOE integrated with whole cell patch clamp. Excitatory and inhibitory neurons are genetically coded in dark and red.

Credit

by Linli Shi, Ying Jiang, Fernando R. Fernandez, Guo Chen, Lu Lan, Heng-ye Man, John A. White, Ji-Xin Cheng, Chen Yang

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