Complex Formation and Reconfiguration of ATAXIN-1 and Capicua (IMAGE)

The Korea Advanced Institute of Science and Technology (KAIST)

Complex Formation and Reconfiguration of ATAXIN-1 and Capicua

Caption

The complex formation between a polyglutamine disease protein, ATXIN-1 and the transcriptional repressor Capicua (CIC) plays a critical role in SCA 1 pathogenesis. The image shows that the homodimerization of ATXIN-1 (yellow and red) is disrupted upon binding of CIC (blue). Furthermore, the binding of CIC to the ATXIN-1 induces a new form of ATXIN-1 dimerization mediated by CICs (ATXIN-1 AXH domains are shown in yellow and red, and CIC peptides shown in blue and white).

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KAIST

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