Walking Uphill as an Enzyme Changes Conformation (IMAGE)

American Institute of Physics

Walking Uphill as an Enzyme Changes Conformation

Caption

Walking uphill as an enzyme (chorismate mutase shown in purple) changes conformation, it moves to a region of the catalytic landscape where its substrate (chorismate in aqua and red) can overcome the energy barrier and reach the transition state. The USC group's present study shows that the dynamics don't contribute to the catalysis of the chemical step.

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Warshel/Bora

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