Example of inflammation in liver after cells are transplanted with or without neutralizing tumor necrosis factor (TNF) (IMAGE)

Elsevier

Example of inflammation in liver after cells are transplanted with or without neutralizing tumor necrosis factor (TNF)

Caption

Activation of monocytes (Kupffer cells) was determined with a pulse of carbon (arrows, black grains). A: Healthy liver with limited carbon incorporation indicates most Kupffer cells are inactive. B: Liver showing an example of extensive carbon uptake six hours after cell transplantation. C: Cell transplantation in the presence of immunosuppression with mycophenolate mofetil and tacrolimus reveals that Kupffer cells remain active. D. Cell transplantation with immunosuppressive drugs plus blocking of TNF prevents Kupffer cell activation. Original magnification, x200. Toluidine blue counterstain.

Credit

Albert Einstein College of Medicine

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.