Brain Circuit Model for Setting Fear Learning Levels (IMAGE)

RIKEN

Brain Circuit Model for Setting Fear Learning Levels

Caption

Early in learning (left) the shock is unexpected and sends a powerful signal to the amygdala (lateral portion, LA) to trigger a memory of the tone-shock association. After learning (right) the tone fully predicts the shock and engages a Feedback circuit from the amygdala (the central portion, CeA) to the PAG and from there to the Medulla and spinal cord to inhibit expected shocks. Ultimately this reduces expected shock responses in the LA and blocks further learning.

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RIKEN

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