Healthy Niche (IMAGE)

Cincinnati Children's Hospital Medical Center

Healthy Niche

Caption

This molecular image shows immunofluorescence staining in the soft spongy section of trabecular bone in the femur of a young mouse. Red staining reveals the abundant presence of the protein osteopontin (OPN) in bone and endosteum of the marrow cavity, which is important to maintaining a healthy environment for blood-forming hematopoietic stem cells. Shown in blue are cell nuclei. Researchers report March 2 in the journal EMBO that restoring depleted osteopontin in aging bone marrow can rejuvenate the production of HSCs. The image was taken by Mehmet Sacma, Institute of Molecular Medicine, University of Ulm, Germany.

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University of Ulm

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