The Long Non-coding RNA Called A-ROD Functions as a Lasso to Recruit Proteins to the DKK1 Gene (IMAGE)

Aarhus University

The Long Non-coding RNA Called A-ROD Functions as a Lasso to Recruit Proteins to the DKK1 Gene

Caption

The authors show that the long non-coding RNA called A-ROD (Activating Regulator Of DKK1 expression) is only functional the moment it is released from chromatin into the nucleoplasm. At this transient phase, it can bring transcription factors -- proteins controlling the synthesis of other genes -- to specific sites in DNA to enhance gene expression. After its complete release from chromatin, A-ROD is no longer active as an enhancing long non-coding RNA.

Credit

Evgenia Ntini

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