The Suv4-20 Effect (IMAGE)

Helmholtz Munich (Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH))

The Suv4-20 Effect

Caption

The figure shows a normal murine embryo (top two panels) and another with additional expression of Suv4-20 (bottom two panels, methylation shown in red). While the cells without histone modification duplicate their DNA (few yellow cells) and progress to cell division, cells with expression of Suv4-20 are trapped in a duplication state (numerous yellow cells) but cannot progress to cell division.

Credit

Source: Helmholtz Zentrum München/Andre Eid

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