Father's Nicotine Use Can Cause Cognitive Problems in Children and Grandchildren (IMAGE)

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Father's Nicotine Use Can Cause Cognitive Problems in Children and Grandchildren

Caption

A photomicrograph of a histological section of a mouse testis processed for immunohistochemistry for methylated DNA. Spermatozoa at different stages of maturation are labeled with the methylated DNA marker (arrow). The data show that nicotine increases DNA methylation in the spermatozoa. Inset shows isolated mature spermatozoa labeled with an immunohistochemical marker for the dopamine D2 receptor (white arrow). Data show that nicotine produces significant changes in DNA methylation in the promoter region of the D2 receptor gene in the spermatozo.

Credit

Pradeep G. Bhide, <a href="mailto:pradeep.bhide@med.fsu.edu">pradeep.bhide@med.fsu.edu</a>

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