Comparing 'Swine' and Seasonal Flu in Ferrets (IMAGE)
Caption
Schematic presentation (A) and a photograph (B) of transmission cages. The ferrets are housed in clear Perspex transmission cages, in which each inoculated animal was housed individually with a naive ferret. The two cages of the inoculated and naive transmission pair were separated by two stainless steel grids (1). Negative pressure within the isolator cage is used to direct a modest flow of high efficiency particulate air (HEPA) filtered air (2) from the inoculated to the naive ferret. The outlet airflow (3) is HEPA filtered to prevent continuous circulation of infectious influenza A virus particles and to prevent crosscontamination with other transmission cages placed in the same isolator cage. Arrows indicate airflow. This image accompanied the paper "Pathogenesis and Transmission of Swine-origin 2009 A/H1N1 Influenza in Ferrets," by V.J. Munster et al. appearing in the July 2, 2009 Science Express.
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