A Cellular Taxonomy of the Visual Cortex (VIDEO)
Caption
The mammalian brain is composed of various cell populations that differ based on their molecular, morphological, electrophysiological and functional characteristics. Classifying these cells into types is one of the essential approaches to defining the diversity of brain's building blocks.
We created a cellular taxonomy of the mouse primary visual cortex by analyzing gene expression patterns, at the single cell level, of more than 1,600 cells. Using transgenic mice, we isolated fluorescently labeled cells from their brains and then sequenced the transcriptomes of individual cells. To identify the different cell types, we employed an iterative unbiased classification method (cluster analysis) that examined all expressed genes and was blind to the origin of cells.
Credit
Allen Institute
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