Critical Genes Unravelled to Understand Human Diseases and Support Drug Discovery (IMAGE)
Caption
Critical paralogs (CP) can conduct the same incoming signal to different cellular responses like cell-death, differentiation, or cell proliferation through cross-talks between signalling pathways. Paralog proteins (PP) are similar to each other and they act very similarly to signals. In drug development, you have to target one critical paralog to reach a specific signal, meanwhile, you have to target all paralog proteins to have a response. Therefore, distinguishing the two paralog types is crucial to identify and rank drug targets.
Credit
Earlham Institute
Usage Restrictions
None
License
Licensed content