Catalytic Mannich Reaction to Synthesize Chiral Imidazolines from Α-Isocyanoacetates and Ketimines (IMAGE)

Nagoya Institute of Technology

Catalytic Mannich Reaction to Synthesize Chiral Imidazolines from Α-Isocyanoacetates and Ketimines

Caption

Authors successfully synthesized high yields of chiral 2-imidazolines (α,β-Tetra-substituted imidazolines) from Ketimins and isocyanides via direct catalytic Mannich reaction. This approach can be a clue to develop novel and effective pharmaceutical products.

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NITech

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