Closing the protein production on-ramps (IMAGE)

Carnegie Institution for Science

Closing the protein production on-ramps

Caption

An illustration of stalled ribosomes as stalled cars on a freeway. New work shows that factors GIGYF2 and 4EHP prevent translation from being initiated on problematic messenger RNA fragments. This is akin to closing an on-ramp to prevent additional traffic backups after an incident.

Credit

Artwork courtesy of Kamena Kostova and Navid Marvi.

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