Follicular Helper T Cells (IMAGE) La Jolla Institute for Immunology Caption Follicular helper T cells (Tfh cells, shown in blue) play a crucial role in the maturation of antibody-producing B cells (shown in green). Activated B cells give rise germinal centers (shown in red), where mature B cells proliferate and produce highly specific antibodies against pathogens. Top left: normal germinal center in a mouse tonsil. All others: Germinal centers fail to form when the interaction between ICOS and TBK1 is interrupted. Credit Courtesy of Dr. Kok-Fai Kong at La Jolla Institute for Allergy and Immunology and Nature Immunology. Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.