Figure: Two Different Pathways in a Humanized Cereblon Mouse Model (IMAGE)

The University of Osaka

Figure: Two Different Pathways in a Humanized Cereblon Mouse Model

Caption

Kishimoto and colleagues found that the degradative effect of IMiDs on IKZF1 and CK-1α, as well as upregulation of IL-2, is dependent on the CRBN-IMiD binding region. Therefore, the anti-inflammatory bowel disease benefit of IMiD is mediated through a CRBN-IMiD binding region-independent pathway.

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Osaka University

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