Computational Design of Large Protein Nanocages (IMAGE)

Howard Hughes Medical Institute

Computational Design of Large Protein Nanocages

Caption

Computational models of the 10 successful designs are shown via molecular surface representations (design names are shown above each model). Each design comprises a pairwise combination of pentameric (grey), trimeric (blue), or dimeric (orange) building blocks aligned along icosahedral fivefold, threefold, and twofold symmetry axes, respectively. All models are shown to scale relative to the 30 nanometer scale bar.

Credit

Jacob Bale, University of Washington

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